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Hydrofiber® Technology aquacel Ag evidence

AQUACEL® Ag dressing evidence

Logo Aquacel Ag

In a primary care setting

AQUACEL® Ag dressing, in a protocol of care, reduced average healing time and more patients healed or improved (p=0.058) compared to a calcium alginate dressing in patients with diabetic foot ulcers over 8 weeks1

A prospective, randomized, controlled, multi-center study in 134 patients comparing AQUACEL® Ag dressing with a calcium alginate dressing in non-ischemic diabetic foot ulcers

  • Decrease in ulcer depth in the AQUACEL® Ag dressing group was twice that in the calcium alginate group (p=0.042)
  • 87.7% of patients healed or improved in the AQUACEL® Ag dressing group vs. 70.8% in the calcium alginate dressing group (p=0.058)
  • Average healing time in the AQUACEL® Ag dressing group was 53±1.8 days vs 58±1.7 days in the calcium alginate group
  • 91.7% of patients requiring systemic antibiotics at baseline healed or improved in the AQUACEL® Ag dressing group vs. 50% in the calcium alginate group (p=0.02)

This study was funded by ConvaTec Inc.

In a primary care setting

AQUACEL® Ag dressing, in a protocol of care, produced an overall mean reduction of 23.9% in wound area over 18 days, with a 32% reduction in leg ulcers infected at baseline2

A multi-center open label non-comparative non-randomized pilot trial study in 15 leg ulcer subjects, with mean ulcer duration of 2.59 years

In patients managed with AQUACEL® Ag dressing over 18 days, compared to baseline

  • Slough decreased from 48.6% to 16.5%
  • Granulation tissue increased from 49.3% to 60.5%
  • Epithelium increased from 1.6% to 21.9%
  • 39% showed “marked”improvement
  • 23.9% reduction in mean ulcer area
  • For ulcers infected at baseline, a mean reduction in area of 32.5% was seen

This study was funded by ConvaTec Inc.

In a primary care setting

AQUACEL® Ag dressing, in a protocol of care, produced a reduction in wound size in 70% of patients with stalled or critically colonized wounds compared to baseline over 4 weeks3

A single-center open-label case series of 30 patients with wounds that had stalled or had the signs and symptoms of critical colonization

In patients managed with AQUACEL® Ag dressing over 4 weeks, compared to baseline

  • 70% of patients demonstrated clinical improvement
  • 27% reduction in mean wound size
  • Majority of participants had a reduction in exudate production
  • Peri-wound maceration improved in 75% of patients

This study was funded by ConvaTec Inc.

In open surgical and traumatic wounds

In patients with open surgical and traumatic wounds, AQUACEL® Ag dressing was more effective for the management of exudate, management of pain in situ and on removal, and ease of use4

A randomized trial of 65 patients, comparing AQUACEL® Ag dressing with povidone-iodine gauze in the management of open surgical and traumatic wounds

  • At final evaluation, AQUACEL® Ag dressing was significantly better than povidone-iodine gauze for overall ability to manage pain (p<0.001)
  • AQUACEL® Ag dressing was significantly better than povidone-iodine gauze in terms of wound trauma on dressing removal (p<0.001) and ease of use (p<0.001)
  • At study completion, 23% of subjects managed with AQUACEL® Ag dressing had healed versus 9% for povidone-iodine gauze, although statistical significance was not achieved
  • AQUACEL® Ag dressing was significantly better than povidone-iodine gauze for the management of exudate (p<0.001)

This study was funded by ConvaTec Inc.

In burns

In patients with partial thickness burns, AQUACEL® Ag dressing was associated with less pain and anxiety at dressing change, fewer dressing changes and less nursing time when compared to treatment with silver sulphadiazine cream for up to 21 days5

A randomized prospective multi-center controlled study in 82 patients with burns, AQUACEL® Ag dressing was compared to standard treatment of silver sulfadiazine cream under gauze dressing in a protocol of care for up to 21 days

Patients managed with AQUACEL® Ag dressing:

  • Reported significantly less self-reported pain (p=0.03) during dressing changes
  • Had significantly fewer dressing changes (p<0.001) with significantly less associated nursing time (p<0.001)

This study was funded by ConvaTec Inc.
 

References [+]

  1. Jude EB, Apelqvist J, Sprault M, Martini J. Prospective randomised controlled study of Hydrofiber dressing containing ionic silver or calcium alginate dressings in non-ischaemic diabetic foot ulcers. Diabetic Medicine. 2007; 24:280-288.
  2. Vanscheidt W, Lazareth I, Routkovsky-Norval. Safety Evaluation of a New Ionic Silver Dressing in the Management of Chronic Ulcers. Wounds. 2003;15:371-378.
  3. Coutts P, Sibbald RG. The effect of a silver-containing Hydrofiber dressing on superficial wound bed and bacterial balance of chronic wounds. Int Wound J. 2005;2(4):348-356.
  4. Jurczak F, Durge T, Johnstone A, Offori T, Vujovic Z, Hollander D et al.Randomised clinical trial of Hydrofiber® dressing with silver versus povidone-iodine gauze in the management of open surgical and traumatic wounds. Int Wound J. 2007;44:66-76.
  5. Caruso DM, Foster KN, Blome-Eberwein SA, et al. Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial thickness burns. J Burn Care Res. 2006 May-Jun;27(3):298-309.